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    frs2 phenylalanine--tRNA (Phe) ligase alpha subunit Frs2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543647, updated on 18-Sep-2024

    Summary

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    Official Symbol
    frs2
    Official Full Name
    phenylalanine--tRNA (Phe) ligase alpha subunit Frs2
    Primary source
    PomBase:SPAC3G9.06
    Locus tag
    SPOM_SPAC3G9.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See frs2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3171544..3173370, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene chromatin modification-related protein Neighboring gene ncRNA Neighboring gene class 1 histone deacetylase Hos2 Neighboring gene ncRNA Neighboring gene GTPase-activating protein Neighboring gene RNA polymerase II CTD phosphatase Ssu72

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway. Han L, et al. PLoS Genet, 2018 Mar. PMID 29596413, Free PMC Article
    2. The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. Calvo IA, et al. iScience, 2021 Nov 19. PMID 34805795, Free PMC Article
    3. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    4. Predicting the fission yeast protein interaction network. Pancaldi V, et al. G3 (Bethesda), 2012 Apr. PMID 22540037, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phenylalanine--tRNA (Phe) ligase alpha subunit Frs2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3171544..3173370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019507.3 → NP_594078.1  phenylalanine--tRNA (Phe) ligase alpha subunit Frs2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594078.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42870
      Conserved Domains (2) summary
      PLN02853
      Location:11 → 496
      PLN02853; Probable phenylalanyl-tRNA synthetase alpha chain
      pfam01409
      Location:208 → 482
      tRNA-synt_2d; tRNA synthetases class II core domain (F)
    Nucleotide Protein
    Heading Accession and Version

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