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    rad51 RecA family recombinase Rad51/Rhp51 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543580, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rad51
    Official Full Name
    RecA family recombinase Rad51/Rhp51
    Primary source
    PomBase:SPAC644.14c
    Locus tag
    SPOM_SPAC644.14C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    loh4; rhp51
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    Genomic context

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    See rad51 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2698110..2700269, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rab GTPase-binding protein Neighboring gene splicing factor Cdc5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribosomal protein P1 Neighboring gene mitochondrial 54S ribosomal protein uL3m Neighboring gene RNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast. Muraszko J, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157114, Free PMC Article
    2. A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors. Afshar N, et al. Elife, 2021 Jan 25. PMID 33493431, Free PMC Article
    3. Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe. Nakamura K, et al. EMBO J, 2008 Nov 19. PMID 18923422, Free PMC Article
    4. Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases. Murayama Y, et al. Nature, 2008 Feb 21. PMID 18256600
    5. Stress activated protein kinase pathway modulates homologous recombination in fission yeast. Bellini A, et al. PLoS One, 2012. PMID 23118915, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fission yeast Swi2 designates cell-type specific donor and stimulates Rad51-driven strand exchange for mating-type switching.
      Title: Fission yeast Swi2 designates cell-type specific donor and stimulates Rad51-driven strand exchange for mating-type switching.
    2. A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors.
      Title: A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors.
    3. Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.
      Title: Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.
    4. ssDNA strand exchange by fission yeast Rad51 proceeds via two distinct three-strand intermediates, C1 and C2
      Title: Two three-strand intermediates are processed during Rad51-driven DNA strand exchange.
    5. These results suggest that Rhp51 and Rad60 are required for the restoration of a stalled or collapsed replication fork after release from the arrest of DNA replication [Rhb51][Rad60]
      Title: Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.
    6. Data show that Rad51-dependent homologous recombination (HR) predominates in centromeres.
      Title: Regulation of mitotic recombination between DNA repeats in centromeres.
    7. Rad51 and Rad54 are required for gene silencing in centromeres, suggesting that homologous recombination also plays a role in the structure and function of centromeres.
      Title: Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.
    8. During replication-coupled DNA repair, CAF-1 promotes Rad51-dependent template switches at replication forks, independently of the postreplication repair pathway.
      Title: The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.
    9. we tentatively suggest that Fbh1 might also have a pro-recombination role in vivo, because the Fbh1-Skp1 complex stimulated Rad51-mediated strand exchange in vitro
      Title: Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.
    10. spindle assembly checkpoint-dependent prometaphase arrest occurred more frequently in pot1Delta rqh1-hd double mutants than in rqh1-hd single mutants in Rad51-dependent recombination intermediates at telomeres
      Title: Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA strand exchange activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Swi5-Sfr1 complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Swi5-Sfr1 complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombinase assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair involved in meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating type switching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic recombination-dependent replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in stalled replication fork localization to nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin NAS
    Non-traceable Author Statement
    more info
    		  
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RecA family recombinase Rad51/Rhp51

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2698110..2700269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019312.3 → NP_593882.1  RecA family recombinase Rad51/Rhp51 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593882.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36601
      Conserved Domains (3) summary
      cd01123
      Location:124 → 356
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR02239
      Location:47 → 360
      recomb_RAD51; DNA repair protein RAD51
      pfam14520
      Location:53 → 102
      HHH_5; Helix-hairpin-helix domain
    Nucleotide Protein
    Heading Accession and Version

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