rhp51 RecA family recombinase Rhp51 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Gene symbol: rhp51
Gene description: RecA family recombinase Rhp51
Primary source: FungiDB:SPAC644.14c
Locus tag: SPAC644.14c
See related: VEuPathDB:SPAC644.14c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: rad51
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Genomic context

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See rhp51 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (2698110..2700283, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fission yeast Swi2 designates cell-type specific donor and stimulates Rad51-driven strand exchange for mating-type switching.
Title: Fission yeast Swi2 designates cell-type specific donor and stimulates Rad51-driven strand exchange for mating-type switching.
A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors.
Title: A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors.
Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.
Title: Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast.
ssDNA strand exchange by fission yeast Rad51 proceeds via two distinct three-strand intermediates, C1 and C2
Title: Two three-strand intermediates are processed during Rad51-driven DNA strand exchange.
These results suggest that Rhp51 and Rad60 are required for the restoration of a stalled or collapsed replication fork after release from the arrest of DNA replication [Rhb51][Rad60]
Title: Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.
Data show that Rad51-dependent homologous recombination (HR) predominates in centromeres.
Title: Regulation of mitotic recombination between DNA repeats in centromeres.
Rad51 and Rad54 are required for gene silencing in centromeres, suggesting that homologous recombination also plays a role in the structure and function of centromeres.
Title: Rad51 and Rad54 promote noncrossover recombination between centromere repeats on the same chromatid to prevent isochromosome formation.
During replication-coupled DNA repair, CAF-1 promotes Rad51-dependent template switches at replication forks, independently of the postreplication repair pathway.
Title: The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.
we tentatively suggest that Fbh1 might also have a pro-recombination role in vivo, because the Fbh1-Skp1 complex stimulated Rad51-mediated strand exchange in vitro
Title: Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.
spindle assembly checkpoint-dependent prometaphase arrest occurred more frequently in pot1Delta rqh1-hd double mutants than in rqh1-hd single mutants in Rad51-dependent recombination intermediates at telomeres
Title: Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	NAS Non-traceable Author Statement more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	IDA Inferred from Direct Assay more info	PubMed
enables DNA strand exchange activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA strand exchange activity	IDA Inferred from Direct Assay more info	PubMed
enables Swi5-Sfr1 complex binding	IDA Inferred from Direct Assay more info	PubMed
enables Swi5-Sfr1 complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA recombinase assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA strand invasion	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome organization involved in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair involved in meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating type switching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic strand invasion	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic recombination-dependent replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in recombinational interstrand cross-link repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	EXP Inferred from Experiment more info	PubMed
involved_in stalled replication fork localization to nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	NAS Non-traceable Author Statement more info
is_active_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RecA family recombinase Rhp51

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

2698110..2700283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019312.2 → NP_593882.1 RecA family recombinase Rhp51 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593882.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P36601

Conserved Domains (3) summary

cd01123
Location:124 → 356

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

TIGR02239
Location:47 → 360

recomb_RAD51; DNA repair protein RAD51

pfam14520
Location:53 → 102

HHH_5; Helix-hairpin-helix domain