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    gls2 glucosidase II alpha subunit Gls2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543277, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gls2
    Official Full Name
    glucosidase II alpha subunit Gls2
    Primary source
    PomBase:SPAC1002.03c
    Locus tag
    SPOM_SPAC1002.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gls2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1799915..1803070, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene nucleoporin Pom34 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene transcription factor TFIID complex subunit Taf11 Neighboring gene histone demethylase Jmj2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate recognition of the catalytic α-subunit of glucosidase II from Schizosaccharomyces pombe. Okuyama M, et al. Biosci Biotechnol Biochem, 2017 Aug. PMID 28471318
    2. Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition. Olson LJ, et al. Biochemistry, 2015 Jul 7. PMID 26062005, Free PMC Article
    3. Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo. Stigliano ID, et al. Mol Biol Cell, 2011 Jun 1. PMID 21471007, Free PMC Article
    4. Glucosidase II beta subunit modulates N-glycan trimming in fission yeasts and mammals. Stigliano ID, et al. Mol Biol Cell, 2009 Sep. PMID 19605557, Free PMC Article
    5. Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity. Arellano M, et al. J Cell Sci, 1999 Oct. PMID 10504305

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Substrate recognition of the catalytic alpha-subunit of glucosidase II from Schizosaccharomyces pombe has been described.
      Title: Substrate recognition of the catalytic α-subunit of glucosidase II from Schizosaccharomyces pombe.
    2. This study reports a 1.6 A resolution crystal structure of the mannose 6-phosphate receptor (MPR) homology domain (MRH) domain of glucosidase II beta bound to mannose.
      Title: Crystal Structure and Functional Analyses of the Lectin Domain of Glucosidase II: Insights into Oligomannose Recognition.
    3. Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo
      Title: Glucosidase II and N-glycan mannose content regulate the half-lives of monoglucosylated species in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables Glc2Man9GlcNAc2 oligosaccharide glucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    part_of glucosidase II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase II alpha subunit Gls2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1799915..1803070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018924.3 → NP_593490.1  glucosidase II alpha subunit Gls2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593490.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9US55
      Conserved Domains (3) summary
      COG1501
      Location:59 → 897
      YicI; Alpha-glucosidase, glycosyl hydrolase family GH31 [Carbohydrate transport and metabolism]
      cd06603
      Location:366 → 834
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:245 → 366
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    Nucleotide Protein
    Heading Accession and Version

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