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    dma1 mitotic spindle checkpoint ubiquitin ligase Dma1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542409, updated on 17-Aug-2024

    Summary

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    Gene symbol
    dma1
    Gene description
    mitotic spindle checkpoint ubiquitin ligase Dma1
    Primary source
    PomBase:SPAC17G8.10c
    Locus tag
    SPOM_SPAC17G8.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dma1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2358028..2359871, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GDT1-like protein Neighboring gene ncRNA Neighboring gene Set1C complex subunit Shg1 Neighboring gene ncRNA Neighboring gene mannosyltransferase Imt3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation. Chen JS, et al. FEBS Lett, 2021 Nov. PMID 34674264, Free PMC Article
    2. Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Wang X, et al. Nat Commun, 2022 Sep 22. PMID 36138017, Free PMC Article
    3. Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization. Jones CM, et al. Mol Biol Cell, 2018 Sep 1. PMID 29975113, Free PMC Article
    4. Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function. Johnson AE, et al. J Biol Chem, 2012 Jul 27. PMID 22669973, Free PMC Article
    5. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Murone M, et al. EMBO J, 1996 Dec 2. PMID 8978687, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro.
      Title: Phosphorylation of Schizosaccharomyces pombe Dss1 mediates direct binding to the ubiquitin-ligase Dma1 in vitro.
    2. Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.
      Title: Localization of the ubiquitin ligase Dma1 to the fission yeast contractile ring is modulated by phosphorylation.
    3. Controlling Dma1's SPB dynamics in anaphase is an essential step in S. pombe cell division and the silencing of the Dma1-dependent mitotic checkpoint.
      Title: Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization.
    4. Dma1 dimerization is required for proper localization at spindle pole bodies and the cell division site, E3 ligase activity, and mitotic checkpoint function
      Title: Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function.
    5. Dma1 functions in parallel with the meiosis-specific Sid2-related protein kinase Slk1/Mug27 and the septation initiation network (SIN) signaling during sporulation, possibly through regulating proper forespore membrane assembly.
      Title: A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast.
    6. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.
      Title: Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of bipolar cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sporulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in division septum EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortical node EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in medial cortical node IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in meiotic spindle pole body EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in meiotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle pole body EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitotic spindle checkpoint ubiquitin ligase Dma1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2358028..2359871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019164.2 → NP_593733.1  mitotic spindle checkpoint ubiquitin ligase Dma1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593733.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10322
      Conserved Domains (3) summary
      COG1716
      Location:1 → 172
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:55 → 139
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam17123
      Location:191 → 219
      zf-RING_11; RING-like zinc finger
    Nucleotide Protein
    Heading Accession and Version

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