asp1 inositol hexakisphosphate kinase/inositol pyrophosphate synthase [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: asp1
Official Full Name: inositol hexakisphosphate kinase/inositol pyrophosphate synthase
Primary source: PomBase:SPCC1672.06c
Locus tag: SPOM_SPCC1672.06C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: vip1
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Genomic context

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See asp1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_003421.2 (571470..574572, complement)

Chromosome III - NC_003421.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003421.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression.
Title: Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression.
The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S](2+) cluster in vivo.
Title: The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S](2+) cluster in vivo.
A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.
Title: A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.
Study provides evidence that Asp1 kinase function is needed for the execution of all three stages of mitosis and controls bipolar spindle stability, chromosome biorientation, and the fidelity of chromosome transmission in Schizosaccharomyces pombe.
Title: Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.
Biochemical and mutagenic studies demonstrated that the [2Fe-2S](2+) cluster substantially inhibits the phosphatase activity of Asp1, thereby increasing its net kinase activity.
Title: Asp1 from Schizosaccharomyces pombe binds a [2Fe-2S](2+) cluster which inhibits inositol pyrophosphate 1-phosphatase activity.
Translin binds the pre-mRNA-splicing factor srp1 and vip1, a protein conserved in fungi.
Title: Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe.
Data show that the S. pombe Asp1 protein, a member of the conserved Vip1 1/3 inositol polyphosphate kinase family, is a key regulator of the morphological switch via the cAMP protein kinase A (PKA) pathway.
Title: Asp1, a conserved 1/3 inositol polyphosphate kinase, regulates the dimorphic switch in Schizosaccharomyces pombe.
Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase activities; the functionality of Asp1 and Vip1 may provide cells with increased signaling capacity through metabolism of IP6
Title: A conserved family of enzymes that phosphorylate inositol hexakisphosphate.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables diphosphoinositol pentakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate 1-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bipolar cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle elongation (spindle phase three)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signaling	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
is_active_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: inositol hexakisphosphate kinase/inositol pyrophosphate synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003421.2 Reference assembly

Range

571470..574572 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022869.3 → NP_587877.1 inositol hexakisphosphate kinase/inositol pyrophosphate synthase [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_587877.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O74429

Conserved Domains (2) summary

pfam00328
Location:387 → 861

His_Phos_2; Histidine phosphatase superfamily (branch 2)

cl17255
Location:241 → 335

ATP-grasp_4; ATP-grasp domain