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    spk1 MAP kinase Spk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542474, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spk1
    Official Full Name
    MAP kinase Spk1
    Primary source
    PomBase:SPAC31G5.09c
    Locus tag
    SPOM_SPAC31G5.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See spk1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2999546..3001518, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Rgg8 Neighboring gene tetraspan protein, claudin Dni1 Neighboring gene uroporphyrinogen-III synthase Ups Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase I termination factor, Myb family Eta2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast. Yamamoto TG, et al. J Cell Sci, 2004 Aug 1. PMID 15265989
    2. Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase. Gotoh Y, et al. Mol Cell Biol, 1993 Oct. PMID 8413241, Free PMC Article
    3. A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans. Halova L, et al. Open Biol, 2021 Apr. PMID 33823663, Free PMC Article
    4. Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression. Yabana N, et al. Mol Cell Biol, 1996 Jul. PMID 8668157, Free PMC Article
    5. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Toda T, et al. Genes Dev, 1991 Jan. PMID 1899230

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activation of Spk1 drives meiosis in S. pombe
      Title: Activation of the pheromone-responsive MAP kinase drives haploid cells to undergo ectopic meiosis with normal telomere clustering and sister chromatid segregation in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables MAP kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase Spk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2999546..3001518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019435.3 → NP_594009.1  MAP kinase Spk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594009.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P27638
      Conserved Domains (2) summary
      smart00220
      Location:39 → 327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07849
      Location:33 → 371
      STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

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