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    ofd1 2-oxoglutarate and Fe(2+) dioxygenase domain-containing protein 1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541179, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ofd1
    Official Full Name
    2-oxoglutarate and Fe(2+) dioxygenase domain-containing protein 1
    Primary source
    PomBase:SPBC6B1.08c
    Locus tag
    SPOM_SPBC6B1.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    uS12
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    Genomic context

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    See ofd1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2644726..2646637, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U4/U6 x U5 tri-snRNP complex subunit Prp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SAGA complex deubiquitinating submodule subunit, TREX complex subunit Sus1 Neighboring gene Mre11 complex BRCT domain subunit Nbs1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Porter JR, et al. Mol Biol Cell, 2012 Sep. PMID 22833559, Free PMC Article
    2. Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member. Hughes BT, et al. EMBO J, 2008 May 21. PMID 18418381, Free PMC Article
    3. Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast. Lee CY, et al. EMBO J, 2009 Jan 21. PMID 19158663, Free PMC Article
    4. Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis. Brookheart RT, et al. J Biol Chem, 2014 Jan 31. PMID 24327658, Free PMC Article
    5. The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor. Yeh TL, et al. Structure, 2011 Apr 13. PMID 21481773, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hydroxylase Ofd1 regulates the Sre1 hypoxic transcription factor in fission yeast by controlling DNA binding.[Sre1; ofd1]
      Title: Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.
    2. The Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and the Ofd1 C-terminal domain accelerates Sre1N degradation.(Sre1)(Ofd1)
      Title: Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.
    3. Data indicate that when oxygen is present, the prolyl hydroxylase Ofd1 down-regulates sterol regulatory element-binding protein Sre1N activity in two ways: first, by inhibiting its binding to DNA, and second, by accelerating its degradation.
      Title: Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.
    4. Studies indicate that the Nro1 NTD binds Ofd1CTDD and stabilizes Sre1N.
      Title: The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.
    5. Ofd1 dioxygenase domain functions as an oxygen sensor that regulates binding of Nro1 to Ofd1 to control oxygen-dependent Sre1N stability.
      Title: Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen sensor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-proline dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-proline dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein sequestering activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2-oxoglutarate and Fe(2+) dioxygenase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2644726..2646637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022001.3 → NP_596087.1  2-oxoglutarate and Fe(2+) dioxygenase domain-containing protein 1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596087.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q11120
      Conserved Domains (2) summary
      COG3751
      Location:3 → 241
      EGL9; Proline 4-hydroxylase (includes Rps23 Pro-64 3,4-dihydroxylase Tpa1), contains SM-20 domain [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]
      pfam10637
      Location:280 → 515
      Ofd1_CTDD; Oxoglutarate and iron-dependent oxygenase degradation C-term
    Nucleotide Protein
    Heading Accession and Version

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