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    dmc1 RecA family ATPase Dmc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542106, updated on 17-Aug-2024

    Summary

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    Gene symbol
    dmc1
    Gene description
    RecA family ATPase Dmc1
    Primary source
    PomBase:SPAC8E11.03c
    Locus tag
    SPOM_SPAC8E11.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    dmp1
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    Genomic context

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    See dmc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (3382264..3383404)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 14-3-3 protein Rad24 Neighboring gene ncRNA Neighboring gene beta-fructofuranosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination. Fukushima K, et al. Nucleic Acids Res, 2000 Jul 15. PMID 10908327, Free PMC Article
    2. Functional interactions of meiotic recombination factors Rdh54 and Dmc1. Chi P, et al. DNA Repair (Amst), 2009 Feb 1. PMID 19028606, Free PMC Article
    3. Crossover invariance determined by partner choice for meiotic DNA break repair. Hyppa RW, et al. Cell, 2010 Jul 23. PMID 20655467, Free PMC Article
    4. The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro. Haruta N, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921379
    5. Fission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filaments. Sauvageau S, et al. Mol Cell Biol, 2005 Jun. PMID 15899844, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
      Title: Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms.
    2. the Swi5-Sfr1 complex from fission yeast is both a mediator that loads Dmc1 onto ssDNA and a direct "activator" of DNA strand exchange by Dmc1
      Title: Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.
    3. Complex formation between Rdh54 and Dmc1 and enhancement of the recombinase activity of Dmc1 by Rdh54, is demonstrated.
      Title: Functional interactions of meiotic recombination factors Rdh54 and Dmc1.
    4. Schizosaccharomyces pombe Swi5-Sfr1 complex, a conserved eukaryotic protein complex, at substoichiometric concentrations stimulates strand exchange mediated by Rhp51 (the S. pombe Rad51 homolog) and Dmc1 on long DNA substrates.
      Title: The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA strand exchange activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Swi5-Sfr1 complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombinase assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic gene conversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic joint molecule formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic strand invasion involved in reciprocal meiotic recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    RecA family ATPase Dmc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3382264..3383404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019590.3 → NP_594166.1  RecA family ATPase Dmc1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594166.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42634, O42880
      Conserved Domains (3) summary
      TIGR02238
      Location:18 → 331
      recomb_DMC1; meiotic recombinase Dmc1
      cd01123
      Location:95 → 328
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam14520
      Location:18 → 73
      HHH_5; Helix-hairpin-helix domain
    Nucleotide Protein
    Heading Accession and Version

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