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    pdi3 disulfide isomerase Pdi3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pdi3
    Official Full Name
    disulfide isomerase Pdi3
    Primary source
    PomBase:SPBC3D6.13c
    Locus tag
    SPOM_SPBC3D6.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pdi2
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    Genomic context

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    See pdi3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1293360..1296026, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene AP-endonuclease Apn2 Neighboring gene ncRNA Neighboring gene SUMO-targeted ubiquitin-protein ligase E3 Slx8 Neighboring gene U3 snoRNA associated protein Dip2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene transmembrane receptor Wsc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe. Lee EH, et al. Mol Biol Rep, 2010 Dec. PMID 20204527
    2. Overexpression of protein disulfide isomerases enhances secretion of recombinant human transferrin in Schizosaccharomyces pombe. Mukaiyama H, et al. Appl Microbiol Biotechnol, 2010 Apr. PMID 20013338
    3. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article
    4. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The S. pombe PDI2 plays a protective role against nitrosative and nutritional stresses, and is positively regulated by nitric oxide and nitrogen starvation in a Pap1-dependent manner.
      Title: A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disulfide isomerase Pdi3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1293360..1296026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021434.3 → NP_595525.1  disulfide isomerase Pdi3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595525.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87178
      UniProtKB/TrEMBL
      D0EJL8
      Conserved Domains (2) summary
      cd02961
      Location:29 → 130
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam13848
      Location:412 → 624
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein
    Heading Accession and Version

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