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    sad1 protein Sad1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539914, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sad1
    Official Full Name
    protein Sad1
    Primary source
    PomBase:SPBC12D12.01
    Locus tag
    SPOM_SPBC12D12.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC16H5.01c
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    Genomic context

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    See sad1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2303766..2306661)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene 6-phosphofructokinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA polymerase delta subunit Cdm1 Neighboring gene chaperonin-containing T-complex alpha subunit Cct1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Nabeshima K, et al. Mol Biol Cell, 1998 Nov. PMID 9802907, Free PMC Article
    2. The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability. Hagan I, et al. J Cell Biol, 1995 May. PMID 7744953, Free PMC Article
    3. Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast. Bestul AJ, et al. Mol Biol Cell, 2021 Aug 1. PMID 34133218, Free PMC Article
    4. S. pombe sporulation-specific coiled-coil protein Spo15p is localized to the spindle pole body and essential for its modification. Ikemoto S, et al. J Cell Sci, 2000 Feb. PMID 10639340
    5. Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication. Paoletti A, et al. Mol Biol Cell, 2003 Jul. PMID 12857865, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
      Title: Redistribution of centrosomal proteins by centromeres and Polo kinase controls partial nuclear envelope breakdown in fission yeast.
    2. kms1 genetically interacts with a number of genes involved in homology-directed repair; these same gene products appear to attenuate the formation or promote resolution of DSB-induced Sad1 foci.
      Title: A role for nuclear envelope-bridging complexes in homology-directed repair.
    3. The functions of Ima1, Sad1, and Kms2 establish a means of communication between the cytoplasm and nucleus that is independent of the nuclear pore complex.
      Title: A network of nuclear envelope membrane proteins linking centromeres to microtubules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spindle pole body-nuclear membrane anchor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centromere clustering at the mitotic interphase nuclear envelope EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in centromere clustering at the mitotic interphase nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic attachment of telomeric heterochromatin to spindle pole body IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle pole body insertion into the nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sad1-Kms1 LINC complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in inner plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in interphase microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in meiotic spindle pole EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in meiotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in new mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in old mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Sad1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2303766..2306661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021855.4 → NP_595947.2  protein Sad1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595947.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09825, Q9UU40
      Conserved Domains (1) summary
      pfam07738
      Location:353 → 487
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version

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