U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rad26 ATR checkpoint kinase regulatory subunit Rad26 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543289, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rad26
    Official Full Name
    ATR checkpoint kinase regulatory subunit Rad26
    Primary source
    PomBase:SPAC9E9.08
    Locus tag
    SPOM_SPAC9E9.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rad26 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (4450605..4453369)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTPase Ypt2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aldehyde dehydrogenase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Fission yeast Rad26 responds to DNA damage independently of Rad3. Wolkow TD, et al. BMC Genet, 2003 Apr 3. PMID 12697061, Free PMC Article
    2. The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization. Baschal EE, et al. BMC Cell Biol, 2006 Aug 24. PMID 16930478, Free PMC Article
    3. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins. Edwards RJ, et al. Nat Cell Biol, 1999 Nov. PMID 10559981
    4. Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin. Hermand D, et al. Mol Cell, 2007 May 25. PMID 17531813
    5. Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity. Win TZ, et al. J Cell Sci, 2004 Sep 15. PMID 15340008

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that Rad26(ATRIP) participates in two genetically defined checkpoint pathways--one that responds to genomic damage and the other to microtubule damage.
      Title: Fission yeast Rad26ATRIP delays spindle-pole-body separation following interphase microtubule damage.
    2. The N-terminus of Nbs1 contributes to the recruitment of Rad3(ATR)-Rad26(ATRIP) to telomeres.
      Title: A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.
    3. data presented here show that two elements of fission yeast DNA structure checkpoints, Rad26 and Rad24, define a pathway that responds to microtubule destabilizing conditions
      Title: The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization.
    4. DNA replication is stalled leads to release of Rad3 and Rad26 from chromatin and entry into an aberrant mitosis.
      Title: Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, telomeric region IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATR-ATRIP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATR checkpoint kinase regulatory subunit Rad26

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4450605..4453369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356167.2 → NP_001342867.1  ATR checkpoint kinase regulatory subunit Rad26 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14292, P36632
      Conserved Domains (1) summary
      pfam09798
      Location:94 → 614
      LCD1; DNA damage checkpoint protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials