U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    srs2 UvrD subfamily ATP-dependent DNA helicase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543577, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    srs2
    Official Full Name
    UvrD subfamily ATP-dependent DNA helicase
    Primary source
    PomBase:SPAC4H3.05
    Locus tag
    SPOM_SPAC4H3.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See srs2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (3832279..3835740)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast. Trickey M, et al. Mol Cell Biol, 2008 Jun. PMID 18426916, Free PMC Article
    2. High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe. Roguev A, et al. Nat Methods, 2007 Oct. PMID 17893680
    3. The severe slow growth of Deltasrs2 Deltarqh1 in Schizosaccharomyces pombe is suppressed by loss of recombination and checkpoint genes. Maftahi M, et al. Nucleic Acids Res, 2002 Nov 1. PMID 12409469, Free PMC Article
    4. The PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast. Tamang S, et al. Elife, 2019 May 31. PMID 31149897, Free PMC Article
    5. Factors affecting template switch recombination associated with restarted DNA replication. Jalan M, et al. Elife, 2019 Jan 22. PMID 30667359, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases.
      Title: Replication stress response in fission yeast differentially depends on maintaining proper levels of Srs2 helicase and Rrp1, Rrp2 DNA translocases.
    2. Authors propose a model placing Rrp1 and Rrp2 functioning together with Swi5 and Srs2 in a synthesis-dependent strand annealing homologous recombination repair pathway.
      Title: Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.
    3. Incubation of conditional srs2 rad3 ( ts ) cells at restrictive temperature led not only to a viability decrease but also to a remarkable shortening of rDNA clusters (approximately 100 copies).
      Title: Redundant roles of Srs2 helicase and replication checkpoint in survival and rDNA maintenance in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic recombination-dependent replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    UvrD subfamily ATP-dependent DNA helicase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3832279..3835740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019762.3 → NP_594341.1  UvrD subfamily ATP-dependent DNA helicase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594341.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10213
      Conserved Domains (4) summary
      COG0210
      Location:9 → 642
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam00580
      Location:11 → 289
      UvrD-helicase; UvrD/REP helicase N-terminal domain
      pfam13538
      Location:587 → 641
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl19114
      Location:395 → 509
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials