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    sec74 guanyl-nucleotide exchange factor Sec74 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542073, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sec74
    Official Full Name
    guanyl-nucleotide exchange factor Sec74
    Primary source
    PomBase:SPAC26F1.01
    Locus tag
    SPOM_SPAC26F1.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAPJ691.01c
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    Genomic context

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    See sec74 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5182774..5186159, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pyruvate dehydrogenase e1 component alpha subunit Pda1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative pinin-like protein ppn1 Neighboring gene ncRNA Neighboring gene yippee-like protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains. Chen JS, et al. Yeast, 2016 Sep. PMID 27168121, Free PMC Article
    2. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    3. Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes. Rallis C, et al. Sci Rep, 2017 Mar 10. PMID 28281664, Free PMC Article
    4. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    guanyl-nucleotide exchange factor Sec74

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5182774..5186159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020323.3 → NP_594894.2  guanyl-nucleotide exchange factor Sec74 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594894.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10491, Q9URW4, Q9UU74
      Conserved Domains (3) summary
      smart00233
      Location:549 → 676
      PH; Pleckstrin homology domain
      pfam00169
      Location:549 → 676
      PH; PH domain
      pfam01369
      Location:308 → 422
      Sec7; Sec7 domain
    Nucleotide Protein
    Heading Accession and Version

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