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    cut15 importin alpha family nuclear import signal receptor adaptor Cut15 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539426, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cut15
    Official Full Name
    importin alpha family nuclear import signal receptor adaptor Cut15
    Primary source
    PomBase:SPCC962.03c
    Locus tag
    SPOM_SPCC962.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cut15 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (549555..552147, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene survivin Bir1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in fission yeast Cut15, an importin alpha homolog, lead to mitotic progression without chromosome condensation. Matsusaka T, et al. Curr Biol, 1998 Sep 10. PMID 9740803
    2. The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression. Umeda M, et al. Genetics, 2005 Sep. PMID 15937127, Free PMC Article
    3. Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4. Khan MG, et al. PLoS One, 2014. PMID 25330182, Free PMC Article
    4. CDK-dependent phosphorylation of Alp7-Alp14 (TACC-TOG) promotes its nuclear accumulation and spindle microtubule assembly. Okada N, et al. Mol Biol Cell, 2014 Jul 1. PMID 24790093, Free PMC Article
    5. Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis. Nakazawa N, et al. J Cell Biol, 2008 Mar 24. PMID 18362178, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Further analysis by pull-down experiments revealed that Php4 is a cargo of the karyopherins Imp1, Cut15 and Sal3.
      Title: Characterization of the nuclear import mechanism of the CCAAT-regulatory subunit Php4.
    2. Cut15p is essential for efficient nuclear protein import in S. pombe.
      Title: The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear import signal receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin alpha family nuclear import signal receptor adaptor Cut15

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      549555..552147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022860.3 → NP_587868.1  importin alpha family nuclear import signal receptor adaptor Cut15 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587868.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14063, Q9UTV5
      Conserved Domains (5) summary
      COG5064
      Location:3 → 531
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:115 → 235
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:8 → 99
      IBB; Importin beta binding domain
      pfam16186
      Location:462 → 501
      Arm_3; Atypical Arm repeat
      sd00043
      Location:116 → 148
      ARM; armadillo repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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