U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tea1 cell end marker Tea1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539047, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tea1
    Official Full Name
    cell end marker Tea1
    Primary source
    PomBase:SPCC1223.06
    Locus tag
    SPOM_SPCC1223.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    alp8
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tea1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1848771..1852620)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DASH complex subunit Spc19 Neighboring gene 60S ribosomal protein eL37 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene aspartate--tRNA (Asp) ligase Drs1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell. Mata J, et al. Cell, 1997 Jun 13. PMID 9200612
    2. Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton. Behrens R, et al. J Cell Biol, 2002 May 27. PMID 12034771, Free PMC Article
    3. Robust polarity specification operates above a threshold of microtubule dynamicity. Thadani R, et al. Cytoskeleton (Hoboken), 2011 May. PMID 21548112
    4. Tea2p is a kinesin-like protein required to generate polarized growth in fission yeast. Browning H, et al. J Cell Biol, 2000 Oct 2. PMID 11018050, Free PMC Article
    5. Role of bud6p and tea1p in the interaction between actin and microtubules for the establishment of cell polarity in fission yeast. Glynn JM, et al. Curr Biol, 2001 Jun 5. PMID 11516644

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study proposes that Cki3 monitors the timing of growth polarity transition from monopolar to bipolar during G2 phase onset through Tea1 phosphorylation by regulating the interaction between Tea1 and Tea4.
      Title: Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.
    2. Study constructed fission yeast strains exhibiting depressed microtubule dynamics by mutating the beta-tubulin gene, nda3. This interfered with efficient accumulation of a polarity factor Tea1 at cell tips.
      Title: Robust polarity specification operates above a threshold of microtubule dynamicity.
    3. Data suggest that rather than acting simply as a Tea1 receptor or as a molecular "glue" to retain Tea1, Mod5 functions catalytically to stimulate incorporation of Tea1 into a stable tip-associated cluster network.
      Title: A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark.
    4. nuclear centering becomes essential when Pom1/Tea1/Tea4 function is compromised and that Kin1 expression level is a key regulatory element in this situation
      Title: Role of the protein kinase Kin1 and nuclear centering in actomyosin ring formation in fission yeast.
    5. results suggest that independent protein-protein interactions among tea1p, tea3p and mod5p collectively contribute to tea1p anchoring at cell tips via a multistep and multimode mechanism
      Title: Multistep and multimode cortical anchoring of tea1p at cell tips in fission yeast.
    6. End4/Sla2 acts downstream of the polarity marker Tea1 and is implicated in the recruitment of the actin cytoskeleton to bring about polarised cell growth
      Title: End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment or maintenance of bipolar cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of bipolar cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to cell cortex of cell tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex of cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytoplasmic microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in division septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton HDA PubMed 
    is_active_in microtubule end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in non-growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in old growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in static microtubule bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cell end marker Tea1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1848771..1852620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023342.3 → NP_588351.1  cell end marker Tea1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588351.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87061
      Conserved Domains (8) summary
      COG0419
      Location:594 → 1121
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00038
      Location:188 → 239
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:242 → 287
      Kelch_1; Kelch motif
      pfam07646
      Location:187 → 236
      Kelch_2; Kelch motif
      pfam13415
      Location:92 → 142
      Kelch_3; Galactose oxidase, central domain
      pfam13418
      Location:292 → 338
      Kelch_4; Galactose oxidase, central domain
      cl21478
      Location:608 → 726
      ATP-synt_B; ATP synthase B/B' CF(0)
      cl23720
      Location:866 → 952
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials