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    gpx1 H2O2 scavenger glutathione peroxidase Gpx1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540222, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gpx1
    Official Full Name
    H2O2 scavenger glutathione peroxidase Gpx1
    Primary source
    PomBase:SPBC32F12.03c
    Locus tag
    SPOM_SPBC32F12.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gpx1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2788863..2789587, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ski complex WD repeat subunit Ski8 Neighboring gene ncRNA Neighboring gene protein Gem7 Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe homologue of glutathione peroxidase, which does not contain selenocysteine, is induced by several stresses and works as an antioxidant. Yamada K, et al. Yeast, 1999 Aug. PMID 10455235
    2. Gpx1 is a stationary phase-specific thioredoxin peroxidase in fission yeast. Lee SY, et al. Biochem Biophys Res Commun, 2008 Feb 29. PMID 18162174
    3. Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe. Kim JS, et al. BMB Rep, 2010 Mar. PMID 20356456
    4. Dissection of a redox relay: H2O2-dependent activation of the transcription factor Pap1 through the peroxidatic Tpx1-thioredoxin cycle. Calvo IA, et al. Cell Rep, 2013 Dec 12. PMID 24316080
    5. A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase. Paulo E, et al. Mol Microbiol, 2014 Apr. PMID 24521463

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutathione peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation.
      Title: Distinct functional roles of peroxiredoxin isozymes and glutathione peroxidase from fission yeast, Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    NOT enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-dependent peroxiredoxin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification of hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    H2O2 scavenger glutathione peroxidase Gpx1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2788863..2789587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022065.3 → NP_596146.1  H2O2 scavenger glutathione peroxidase Gpx1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596146.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59858
      Conserved Domains (1) summary
      COG0386
      Location:1 → 158
      BtuE; Glutathione peroxidase, house-cleaning role in reducing lipid peroxides [Defense mechanisms, Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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