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    hsp90 Hsp90 chaperone [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543539, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hsp90
    Official Full Name
    Hsp90 chaperone
    Primary source
    PomBase:SPAC926.04c
    Locus tag
    SPOM_SPAC926.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    git10; swo1
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    Genomic context

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    See hsp90 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3888558..3891139, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Ina22 Neighboring gene myosin II regulatory light chain Rlc1 Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene diphthamide biosynthesis protein Dph4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission yeast. Sun L, et al. J Cell Sci, 2020 Jul 7. PMID 32499408
    2. How does Hsp90 function in RNAi-dependent heterochromatin assembly? Kato H, et al. Curr Genet, 2019 Feb. PMID 29974204
    3. Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe. Shiozaki K, et al. Mol Cell Biol, 1994 Jun. PMID 8196617, Free PMC Article
    4. Genetic interactions between Hsp90 and the Cdc2 mitotic machinery in the fission yeast Schizosaccharomyces pombe. Muñoz MJ, et al. Mol Gen Genet, 1999 Mar. PMID 10102358
    5. Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast. Ki SW, et al. Biosci Biotechnol Biochem, 2001 Nov. PMID 11791728

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies suggest that it is possible that heat-shock protein 90 (Hsp90) and other molecular chaperones contribute to the modulation of still-unknown factors that regulate the intracellular heterochromatin assembly process [Review].
      Title: How does Hsp90 function in RNAi-dependent heterochromatin assembly?
    2. Study identified the S. pombe molecular chaperone proteins Hsp90 and Mas5 as novel regulators of RNAi-dependent heterochromatin assembly. Mutations in the genes encoding these proteins caused derepression of transcriptional silencing and decreases in H3K9me at the pericentromeric heterochromatin region, while having little effect on the subtelomeric heterochromatin, which can be maintained in the absence of RNAi.
      Title: RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5.
    3. Cochaperones can modify Hsp90 by strengthening of the coupling between ATP hydrolysis and a kinetic step involved in the Hsp90 system resulting in a stronger directionality.
      Title: Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery.
    4. The co-chaperones Sti1 and Aha1 bound Hsp90 and modulated its activity
      Title: Biochemical characterization and cooperation with co-chaperones of heat shock protein 90 from Schizosaccharomyces pombe.
    5. cochaperone Hsp90 may not be essential for Cdc37 function in S. pombe
      Title: Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90.
    6. Analyses of Myo2p, Swo1p, and the UCS domain protein Rng3p establish that Swo1p and Rng3p collaborate in vivo to modulate myosin II function.
      Title: Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' cotranslational protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in protein aggregate center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hsp90 chaperone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3888558..3891139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019786.3 → NP_594365.1  Hsp90 chaperone [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594365.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41887, Q9UUG4
      Conserved Domains (3) summary
      cd00075
      Location:29 → 161
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      PTZ00272
      Location:4 → 704
      PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
      pfam00183
      Location:185 → 704
      HSP90; Hsp90 protein
    Nucleotide Protein
    Heading Accession and Version

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