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    tif211 translation initiation factor eIF2 alpha subunit [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543455, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tif211
    Official Full Name
    translation initiation factor eIF2 alpha subunit
    Primary source
    PomBase:SPAC3G9.09c
    Locus tag
    SPOM_SPAC3G9.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    eIF2alpha
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    Genomic context

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    See tif211 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3166428..3167699)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene chromatin modification-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene class 1 histone deacetylase Hos2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint. Krohn M, et al. J Cell Sci, 2008 Dec 15. PMID 19033384
    2. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Zhan K, et al. Mol Cell Biol, 2002 Oct. PMID 12242291, Free PMC Article
    3. Crystal structure of eIF2B and insights into eIF2-eIF2B interactions. Kashiwagi K, et al. FEBS J, 2017 Mar. PMID 27627185
    4. Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe. Berlanga JJ, et al. Eukaryot Cell, 2010 Jan. PMID 19880757, Free PMC Article
    5. Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis. Wang YT, et al. Mol Cell Biol, 2019 Oct 1. PMID 31285271, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl nucleotide exchange factor inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables methionyl-initiator methionine tRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-tRNA adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF2 alpha subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3166428..3167699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019504.3 → NP_594081.1  translation initiation factor eIF2 alpha subunit [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594081.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P56286
      Conserved Domains (3) summary
      cd04452
      Location:14 → 89
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      PTZ00248
      Location:5 → 306
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
      pfam07541
      Location:127 → 235
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit
    Nucleotide Protein
    Heading Accession and Version

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