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    caf1 CCR4-Not complex CAF1 family ribonuclease subunit 7/8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539041, updated on 18-Sep-2024

    Summary

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    Official Symbol
    caf1
    Official Full Name
    CCR4-Not complex CAF1 family ribonuclease subunit 7/8
    Primary source
    PomBase:SPCC18.06c
    Locus tag
    SPOM_SPCC18.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pop2
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    Genomic context

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    See caf1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1965430..1966906, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosome biogenesis protein Rsa4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene oligosaccharyltransferase complex zeta subunit Ost5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme. Jonstrup AT, et al. Nucleic Acids Res, 2007. PMID 17452359, Free PMC Article
    2. A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading. Challal D, et al. Genetics, 2023 Aug 9. PMID 37279920, Free PMC Article
    3. The activity and selectivity of fission yeast Pop2p are affected by a high affinity for Zn2+ and Mn2+ in the active site. Andersen KR, et al. RNA, 2009 May. PMID 19307292, Free PMC Article
    4. Accumulation of RNA on chromatin disrupts heterochromatic silencing. Brönner C, et al. Genome Res, 2017 Jul. PMID 28404620, Free PMC Article
    5. Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly. Takahashi S, et al. Nucleic Acids Res, 2007. PMID 17264117, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During replication-coupled DNA repair, CAF-1 promotes Rad51-dependent template switches at replication forks, independently of the postreplication repair pathway.
      Title: The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.
    2. crystallographic analysis of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (Hip1B) and the C-terminal region of the Cac2 subunit of CAF-1 (Cac2C)
      Title: Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus.
    3. The 1.4-A crystal structure of the Pop2 deadenylase subunit reveals a fully conserved DEDDh active site, and allowed for a detailed analysis of its configuration, including divalent metal ion binding.
      Title: The 1.4-A crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables chromatin binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables manganese ion binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    CCR4-Not complex CAF1 family ribonuclease subunit 7/8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1965430..1966906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023376.3 → NP_588385.2  CCR4-Not complex CAF1 family ribonuclease subunit 7/8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588385.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74856
      Conserved Domains (1) summary
      COG5228
      Location:4 → 314
      POP2; mRNA deadenylase subunit [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version

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