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    sid4 SIN component scaffold protein Sid4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540650, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sid4
    Official Full Name
    SIN component scaffold protein Sid4
    Primary source
    PomBase:SPBC244.01c
    Locus tag
    SPOM_SPBC244.01C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sid4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4360626..4363926)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Utp6 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein mL57 Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization. Jones CM, et al. Mol Biol Cell, 2018 Sep 1. PMID 29975113, Free PMC Article
    2. Fission yeast Dma1 requires RING domain dimerization for its ubiquitin ligase activity and mitotic checkpoint function. Johnson AE, et al. J Biol Chem, 2012 Jul 27. PMID 22669973, Free PMC Article
    3. Mug27 is a meiosis-specific protein kinase that functions in fission yeast meiosis II and sporulation. Ohtaka A, et al. J Cell Sci, 2008 May 1. PMID 18411246
    4. The spindle pole body protein Cdc11p links Sid4p to the fission yeast septation initiation network. Tomlin GC, et al. Mol Biol Cell, 2002 Apr. PMID 11950932, Free PMC Article
    5. Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase. Johnson AE, et al. EMBO J, 2011 Jan 19. PMID 21131906, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signals from Sid4 contribute to the Cut12 mitotic commitment switch.
      Title: Dialogue between centrosomal entrance and exit scaffold pathways regulates mitotic commitment.
    2. Sid4 ubiquitination by Dma1 delays recruitment of the Polo-like kinase and SIN activator, Plo1, to spindle pole bodies, and is required to prevent cytokinesis during a mitotic checkpoint arrest.
      Title: Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cytokinesis EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in septation initiation signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in meiotic spindle pole EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in outer plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SIN component scaffold protein Sid4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4360626..4363926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023834.3 → NP_596814.1  SIN component scaffold protein Sid4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596814.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60187
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials