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    spp42 U5 snRNP complex subunit Spp42 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543413, updated on 18-Sep-2024

    Summary

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    Official Symbol
    spp42
    Official Full Name
    U5 snRNP complex subunit Spp42
    Primary source
    PomBase:SPAC4F8.12c
    Locus tag
    SPOM_SPAC4F8.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cwf6
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    Genomic context

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    See spp42 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2650719..2658024)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene IQ motif containing GTPase activating protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SEACAT complex subunit Sea2 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome. Casalino L, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891649, Free PMC Article
    2. spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p. Schmidt H, et al. Genetics, 1999 Nov. PMID 10545451, Free PMC Article
    3. Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe. Bottner CA, et al. Curr Genet, 2005 Sep. PMID 16133344
    4. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
    5. Genome-wide mapping of myosin protein-RNA networks suggests the existence of specialized protein production sites. Mata J. FASEB J, 2010 Feb. PMID 19805578

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U5 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISM
    Inferred from Sequence Model
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in spliceosomal conformational changes to generate catalytic conformation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    U5 snRNP complex subunit Spp42

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2650719..2658024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019290.3 → NP_593861.1  U5 snRNP complex subunit Spp42 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593861.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14187
      Conserved Domains (1) summary
      COG5178
      Location:33 → 2363
      PRP8; U5 snRNP spliceosome subunit [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version

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