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    dip1 endocytosis protein Dip1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540504, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dip1
    Official Full Name
    endocytosis protein Dip1
    Primary source
    PomBase:SPBC24C6.10c
    Locus tag
    SPOM_SPBC24C6.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See dip1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (2341402..2343170, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome c oxidase subunit VIb related protein Neighboring gene G10 protein Neighboring gene DNA mismatch repair protein Neighboring gene ncRNA Neighboring gene 4-amino-4-deoxychorismate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly. Liu SL, et al. J Biol Chem, 2022 Jun. PMID 35533728, Free PMC Article
    2. Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks. Balzer CJ, et al. Elife, 2020 Nov 12. PMID 33179595, Free PMC Article
    3. Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex. Balzer CJ, et al. Curr Biol, 2018 Dec 3. PMID 30471998, Free PMC Article
    4. Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments. Wagner AR, et al. Curr Biol, 2013 Oct 21. PMID 24120641, Free PMC Article
    5. Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis. Basu R, et al. Curr Biol, 2011 Jun 7. PMID 21620704, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly.
      Title: Analysis of functional surfaces on the actin nucleation promoting factor Dip1 required for Arp2/3 complex activation and endocytic actin network assembly.
    2. Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks.
      Title: Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks.
    3. Dip1, the S. pombe WISH/DIP/SPIN90 (WDS) protein, co-opts features of branching nucleation to activate Arp2/3 complex. Specifically, it activates Arp2/3 complex to nucleate linear filaments analogous to the branch created by WASP-mediated activation.
      Title: Dip1 Co-opts Features of Branching Nucleation to Create Linear Actin Filaments that Activate WASP-Bound Arp2/3 Complex.
    4. The mechanism by which Dip1 and other WISH/DIP/SPIN90 proteins can provide seed filaments to Arp2/3 complex to serve as master switches in initiating branched actin assembly. This mechanism is distinct from other known activators of Arp2/3 complex.
      Title: Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in actin cortical patch assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to actin cortical patch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endocytosis protein Dip1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2341402..2343170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356255.2 → NP_001342760.1  endocytosis protein Dip1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74771
      Conserved Domains (1) summary
      pfam09431
      Location:199 → 328
      DUF2013; Protein of unknown function (DUF2013)
    Nucleotide Protein
    Heading Accession and Version

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