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    MRX10 Mrx10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851876, updated on 29-Jun-2024

    Summary

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    Gene symbol
    MRX10
    Gene description
    Mrx10p
    Primary source
    FungiDB:YDR282C
    Locus tag
    YDR282C
    See related
    SGD:S000002690; AllianceGenome:SGD:S000002690; VEuPathDB:YDR282C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in positive regulation of mitochondrial translation. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 11. Orthologous to human RMND1 (required for meiotic nuclear division 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRX10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1023511..1024755, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP45 Neighboring gene Phm6p Neighboring gene serine/threonine-protein kinase GCN2 Neighboring gene bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Infantile encephaloneuromyopathy and defective mitochondrial translation are due to a homozygous RMND1 mutation. Garcia-Diaz B, et al. Am J Hum Genet, 2012 Oct 5. PMID 23022099, Free PMC Article
    2. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
    3. VID22 counteracts G-quadruplex-induced genome instability. Galati E, et al. Nucleic Acids Res, 2021 Dec 16. PMID 34871443, Free PMC Article
    4. Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. Pereira F, et al. PLoS One, 2019. PMID 30682149, Free PMC Article
    5. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mrx10p
    NP_010568.3
    • Mitochondrial inner membrane hypothetical protein; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1023511..1024755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180590.3 → NP_010568.3  TPA: Mrx10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010568.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSR2, Q05648
      UniProtKB/TrEMBL
      A0A8H8UNI4, A6ZYN1, B3LG12, B5VGG0, C7GQT4, C8Z5J5, G2WB21, N1P716
      Conserved Domains (1) summary
      COG1723
      Location:32 → 405
      Rmd1; Uncharacterized protein, Rmd1/YagE family [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05648.1

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