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    CMC1 Cmc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853721, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CMC1
    Official Full Name
    Cmc1p
    Primary source
    SGD:S000001620
    Locus tag
    YKL137W
    See related
    AllianceGenome:SGD:S000001620; FungiDB:YKL137W; VEuPathDB:YKL137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables copper ion binding activity. Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human CMC1 (C-X9-C motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CMC1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (185957..186292)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Hsk3p Neighboring gene mitochondrial 54S ribosomal protein YmL31 Neighboring gene Apl2p Neighboring gene metalloendopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding. Peleh V, et al. Elife, 2016 Jun 25. PMID 27343349, Free PMC Article
    2. Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1. Bourens M, et al. J Biol Chem, 2012 Sep 7. PMID 22767599, Free PMC Article
    3. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131, Free PMC Article
    4. Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Bode M, et al. Antioxid Redox Signal, 2013 May 1. PMID 23198688, Free PMC Article
    5. Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis. Horn D, et al. Mol Cell Biol, 2008 Jul. PMID 18443040, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1.
      Title: Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1.
    2. These results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p.
      Title: Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cmc1p
    NP_012785.2
    • Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      185957..186292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179703.1 → NP_012785.2  TPA: Cmc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012785.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZI5, B3LQW4, D6VX60, P36064
      UniProtKB/TrEMBL
      C7GVI0, C8ZC39, G2WHQ2, N1P158
      Conserved Domains (1) summary
      pfam08583
      Location:30 → 97
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36064.2

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