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    ARG2 acetyl-CoA:L-glutamate N-acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853374, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARG2
    Official Full Name
    acetyl-CoA:L-glutamate N-acetyltransferase
    Primary source
    SGD:S000003607
    Locus tag
    YJL071W
    See related
    AllianceGenome:SGD:S000003607; FungiDB:YJL071W; VEuPathDB:YJL071W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRB574
    Summary
    Enables acetyl-CoA:L-glutamate N-acetyltransferase activity. Involved in ornithine biosynthetic process. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in N-acetylglutamate synthase deficiency and amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARG2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (306132..307856)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Jem1p Neighboring gene DNA replication protein PSF2 Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene Utp18p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel suppressors of alpha-synuclein toxicity identified using yeast. Liang J, et al. Hum Mol Genet, 2008 Dec 1. PMID 18772193, Free PMC Article
    2. A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis: acetylglutamate synthase activity requires complex formation with acetylglutamate kinase. Abadjieva A, et al. J Biol Chem, 2001 Nov 16. PMID 11553611
    3. An antioxidative mechanism mediated by the yeast N-acetyltransferase Mpr1: oxidative stress-induced arginine synthesis and its physiological role. Nishimura A, et al. FEMS Yeast Res, 2010 Sep. PMID 20550582
    4. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain. Dickinson Q, et al. Microb Cell Fact, 2016 Jan 20. PMID 26790958, Free PMC Article
    5. Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Vandenbol M, et al. Yeast, 1999 Sep 30. PMID 10509023

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-glutamate N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glutamate N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-glutamate N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ornithine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ornithine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA:L-glutamate N-acetyltransferase
    NP_012464.1
    • Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      306132..307856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181504.1 → NP_012464.1  TPA: acetyl-CoA:L-glutamate N-acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LQ40, D6VWB2, P40360
      UniProtKB/TrEMBL
      C7GR42, C8ZBE2, N1P8G8
      Conserved Domains (1) summary
      COG5630
      Location:1 → 569
      Arg2; Acetylglutamate synthase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40360.1

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