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    PPG1 putative serine/threonine-protein kinase PPG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PPG1
    Official Full Name
    putative serine/threonine-protein kinase PPG1
    Primary source
    SGD:S000005315
    Locus tag
    YNR032W
    See related
    AllianceGenome:SGD:S000005315; FungiDB:YNR032W; VEuPathDB:YNR032W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in glycogen metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PPG1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (686010..687116)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase Neighboring gene mitogen-activated protein kinase kinase kinase SSK2 Neighboring gene ubiquitin-like protein HUB1 Neighboring gene 4-amino-4-deoxychorismate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene PPG encodes a novel yeast protein phosphatase involved in glycogen accumulation. Posas F, et al. J Biol Chem, 1993 Jan 15. PMID 7678255
    2. PP2A-like protein phosphatase Ppg1: an emerging negative regulator of mitophagy in yeast. Furukawa K, et al. Autophagy, 2018. PMID 30145928, Free PMC Article
    3. The nascent polypeptide-associated complex subunit Egd1 is required for efficient selective mitochondrial degradation in budding yeast. Tian Y, et al. Sci Rep, 2024 Jan 4. PMID 38177147, Free PMC Article
    4. Mitophagy regulation mediated by the Far complex in yeast. Furukawa K, et al. Autophagy, 2021 Apr. PMID 33530805, Free PMC Article
    5. Deciphering cellular functions of protein phosphatases by comparison of gene expression profiles in Saccharomyces cerevisiae. Hirasaki M, et al. J Biosci Bioeng, 2010 May. PMID 20347764

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization to old mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of organelle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    putative serine/threonine-protein kinase PPG1
    NP_014429.3
    • Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      686010..687116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183209.3 → NP_014429.3  TPA: putative serine/threonine-protein kinase PPG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014429.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1K6, E9P8U5, P32838
      UniProtKB/TrEMBL
      A6ZSA5, B3LPL2, C7GLM6, C8ZFQ9, G2WL88, N1NZR3
      Conserved Domains (1) summary
      cd07415
      Location:2 → 299
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32838.2

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