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    PUS6 pseudouridine synthase PUS6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853079, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PUS6
    Official Full Name
    pseudouridine synthase PUS6
    Primary source
    SGD:S000003401
    Locus tag
    YGR169C
    See related
    AllianceGenome:SGD:S000003401; FungiDB:YGR169C; VEuPathDB:YGR169C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pseudouridine synthase activity. Involved in tRNA pseudouridine synthesis. Located in mitochondrion. Orthologous to human RPUSD2 (RNA pseudouridine synthase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PUS6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (834689..835903, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Clc1p Neighboring gene Pex35p Neighboring gene Lso2p Neighboring gene phosphatidylserine decarboxylase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae. Ansmant I, et al. J Biol Chem, 2001 Sep 14. PMID 11406626
    2. Transcriptome-wide mapping of pseudouridines: pseudouridine synthases modify specific mRNAs in S. cerevisiae. Lovejoy AF, et al. PLoS One, 2014. PMID 25353621, Free PMC Article
    3. An investigation into eukaryotic pseudouridine synthases. King RD, et al. J Bioinform Comput Biol, 2014 Aug. PMID 25152040
    4. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Carlile TM, et al. Nature, 2014 Nov 6. PMID 25192136, Free PMC Article
    5. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Schwartz S, et al. Cell, 2014 Sep 25. PMID 25219674, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase.
      Title: Pseudouridine-mediated translation control of mRNA by methionine aminoacyl tRNA synthetase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA pseudouridine(31) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridine synthase PUS6
    NP_011685.3
    • tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      834689..835903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181298.3 → NP_011685.3  TPA: pseudouridine synthase PUS6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011685.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV2, P53294
      UniProtKB/TrEMBL
      A6ZUH9, B3LI62, N1P464
      Conserved Domains (1) summary
      cd02557
      Location:104 → 400
      PseudoU_synth_ScRIB2; Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53294.1

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