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    MGT1 methylated-DNA--protein-cysteine methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851327, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGT1
    Official Full Name
    methylated-DNA--protein-cysteine methyltransferase
    Primary source
    SGD:S000002359
    Locus tag
    YDL200C
    See related
    AllianceGenome:SGD:S000002359; FungiDB:YDL200C; VEuPathDB:YDL200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in DNA dealkylation involved in DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MGT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (100501..101067, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene tRNA (guanine46-N7)-methyltransferase Neighboring gene uncharacterized protein Neighboring gene Ggc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions. Xiao W, et al. Nucleic Acids Res, 1992 Jul 25. PMID 1641326, Free PMC Article
    2. Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases. Sassanfar M, et al. J Biol Chem, 1991 Feb 15. PMID 1993655
    3. Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. Xiao W, et al. EMBO J, 1991 Aug. PMID 2065659, Free PMC Article
    4. Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae. Sassanfar M, et al. J Biol Chem, 1990 Jan 5. PMID 2403555
    5. Expression of yeast O6-methylguanine-DNA methyltransferase (MGMT) gene. Joo JH, et al. Cell Mol Biol (Noisy-le-grand), 1995 Jun. PMID 7549791

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of how proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
      Title: Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    NP_010081.2
    • DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; localizes to the peroxisome in a Pex5p-dependent manner

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      100501..101067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180260.1 → NP_010081.2  TPA: methylated-DNA--protein-cysteine methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010081.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZXD3, D6VRF4, P26188
      UniProtKB/TrEMBL
      B5VF77, C7GV61, C8Z6A5, G2WBW7, N1PAF9
      Conserved Domains (1) summary
      COG0350
      Location:5 → 179
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26188.3

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