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    HEM3 hydroxymethylbilane synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851322, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEM3
    Official Full Name
    hydroxymethylbilane synthase
    Primary source
    SGD:S000002364
    Locus tag
    YDL205C
    See related
    AllianceGenome:SGD:S000002364; FungiDB:YDL205C; VEuPathDB:YDL205C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OLE2
    Summary
    Enables hydroxymethylbilane synthase activity. Involved in heme biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HEM3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (92762..93745, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene nucleoporin GLE1 Neighboring gene Ycx1p Neighboring gene uncharacterized protein Neighboring gene Rtn2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of hem3 mutants from Candida albicans by sequential gene disruption. Kurtz MB, et al. Mol Gen Genet, 1989 May. PMID 2671651
    2. Unsaturated fatty acid mutants of Saccharomyces cerevisiae. Resnick MA, et al. J Bacteriol, 1966 Sep. PMID 5922535, Free PMC Article
    3. Structure and regulation of yeast HEM3, the gene for porphobilinogen deaminase. Keng T, et al. Mol Gen Genet, 1992 Aug. PMID 1508149
    4. Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7. Kawasaki S, et al. Proc Natl Acad Sci U S A, 1985 Sep. PMID 3898069, Free PMC Article
    5. Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Gachotte D, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811880, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydroxymethylbilane synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylbilane synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylbilane synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-pyrromethane cofactor linkage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    hydroxymethylbilane synthase
    NP_010076.1
    • Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      92762..93745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180265.1 → NP_010076.1  TPA: hydroxymethylbilane synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRE9, P28789, Q2VQW9
      UniProtKB/TrEMBL
      A6ZXC8, B3LH85, C7GV66, C8Z6A1, G2WBW2, N1P4V9
      Conserved Domains (1) summary
      cd13645
      Location:5 → 291
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28789.1

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