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    ACK1 Ack1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851324, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACK1
    Official Full Name
    Ack1p
    Primary source
    SGD:S000002362
    Locus tag
    YDL203C
    See related
    AllianceGenome:SGD:S000002362; FungiDB:YDL203C; VEuPathDB:YDL203C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in fungal-type cell wall organization and positive regulation of signal transduction. Located in mitochondrion. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human DELE1 (DAP3 binding cell death enhancer 1); SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase); and SEL1L2 (SEL1L2 adaptor subunit of ERAD E3 ligase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ACK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (96082..97953, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rtn2p Neighboring gene mitochondrial 54S ribosomal protein YmL11 Neighboring gene tRNA (guanine46-N7)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The functional relationships underlying a synthetic genetic network. Krause SA, et al. Commun Integr Biol, 2009. PMID 19704853, Free PMC Article
    2. A high throughput screen to identify substrates for the ubiquitin ligase Rsp5. Kus B, et al. J Biol Chem, 2005 Aug 19. PMID 15955809
    3. The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose. Defenouillère Q, et al. Sci Signal, 2019 Sep 3. PMID 31481524
    4. Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Piotrowski JS, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775513, Free PMC Article
    5. The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Krause SA, et al. Eukaryot Cell, 2008 Nov. PMID 18806213, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Ack1p
    NP_010078.1
    • Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      96082..97953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180263.1 → NP_010078.1  TPA: Ack1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF1, Q07622
      UniProtKB/TrEMBL
      G2WBW4, N1P8D5
      Conserved Domains (3) summary
      smart00671
      Location:318 → 361
      SEL1; Sel1-like repeats
      COG0790
      Location:342 → 623
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:345 → 374
      SLR; SLR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07622.1

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