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    Acaa1b acetyl-Coenzyme A acyltransferase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501072, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Acaa1bprovided by RGD
    Official Full Name
    acetyl-Coenzyme A acyltransferase 1Bprovided by RGD
    Primary source
    RGD:1562373
    See related
    EnsemblRapid:ENSRNOG00000067803 AllianceGenome:RGD:1562373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562373
    Summary
    Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Located in peroxisome. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 227.8), Liver (RPKM 177.5) and 4 other tissues See more
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    Genomic context

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    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (127750771..127759589, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (118872996..118881852, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (127836235..127845296, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene villin-like Neighboring gene phospholipase C, delta 1 Neighboring gene uncharacterized LOC102548352 Neighboring gene DLEC1 cilia and flagella associated protein Neighboring gene solute carrier family 22, member 14 Neighboring gene solute carrier family 22 member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. Hijikata M, et al. J Biol Chem, 1987 Jun 15. PMID 3036803
    2. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes. Hijikata M, et al. J Biol Chem, 1990 Mar 15. PMID 2307679
    3. A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. Swinkels BW, et al. EMBO J, 1991 Nov. PMID 1680677, Free PMC Article
    4. Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins. Ghys K, et al. Biochem J, 2002 Jul 1. PMID 11931631, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetyl-CoA C-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA C-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA C-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-ketoacyl-CoA thiolase B, peroxisomal
    Names
    acetyl-CoA acyltransferase B
    beta-ketothiolase B
    peroxisomal 3-ketoacyl-CoA thiolase B
    peroxisomal 3-oxoacyl-CoA thiolase B
    NP_001035108.2
    XP_038937924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040019.3 → NP_001035108.2  3-ketoacyl-CoA thiolase B, peroxisomal precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P07871, Q4G049
      UniProtKB/TrEMBL
      A0A8I6AEX9, A6I3V2
      Related
      ENSRNOP00000086036.1, ENSRNOT00000106186.2
      Conserved Domains (1) summary
      PLN02287
      Location:1 → 420
      PLN02287; 3-ketoacyl-CoA thiolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      127750771..127759589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081996.2 → XP_038937924.1  3-ketoacyl-CoA thiolase B, peroxisomal isoform X1

      Conserved Domains (1) summary
      PLN02287
      Location:1 → 333
      PLN02287; 3-ketoacyl-CoA thiolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07871.2 GenPept UniProtKB/Swiss-Prot:P07871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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