Mogs mannosyl-oligosaccharide glucosidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mogsprovided by RGD
Full Name: mannosyl-oligosaccharide glucosidaseprovided by RGD
Primary source: RGD:69240
See related: EnsemblRapid:ENSRNOG00000054176 AllianceGenome:RGD:69240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gcs1
Summary: Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 170.5), Kidney (RPKM 152.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117179335..117182738)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115621623..115625026)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (113948328..113951731)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

D15Rat29 (e-PCR)
- UniSTS:119306

NoName (e-PCR)
- UniSTS:546869

Mogs (e-PCR), detects polymorphism
- UniSTS:546869

RH140742 (e-PCR)
- UniSTS:222808

D15Mgh4 (e-PCR)
- UniSTS:119420

d15rat102 (e-PCR)
- UniSTS:121036

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oligosaccharide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mannosyl-oligosaccharide glucosidase

Names: glucosidase 1; glycoprotein-processing glucosidase I

NP_113937.2

EC 3.2.1.106

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031749.3 → NP_113937.2 mannosyl-oligosaccharide glucosidase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O88941

UniProtKB/TrEMBL

A0A0G2K8S6, A6IAK3

Related

ENSRNOP00000074720.1, ENSRNOT00000083560.3

Conserved Domains (2) summary

pfam03200
Location:349 → 832

Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain

pfam16923
Location:92 → 260

Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain