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    St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64445, updated on 10-Oct-2024

    Summary

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    Official Symbol
    St3gal3provided by RGD
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by RGD
    Primary source
    RGD:68414
    See related
    EnsemblRapid:ENSRNOG00000019843 AllianceGenome:RGD:68414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ST3N; Siat6; ST3GalIII; ST3Gal III
    Summary
    Predicted to enable beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process via lactosylceramide and protein glycosylation. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 46.2), Liver (RPKM 34.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See St3gal3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136755780..136958081, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131470348..131670794, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136765309..136965642, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene importin 13 Neighboring gene uncharacterized LOC120102961 Neighboring gene artemin Neighboring gene uncharacterized LOC120102959 Neighboring gene uncharacterized LOC120102960 Neighboring gene uncharacterized LOC134486979 Neighboring gene lysine demethylase 4A Neighboring gene protein tyrosine phosphatase, receptor type, F Neighboring gene uncharacterized LOC102553423

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. Pérez-Garay M, et al. PLoS One, 2010 Sep 1. PMID 20824144, Free PMC Article
    2. Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family. Wen DX, et al. J Biol Chem, 1992 Oct 15. PMID 1400416
    3. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. St3gal3 modulates pancreatic cancer cell motility and adhesion and enhances metastatic potential.
      Title: alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process via lactosylceramide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
    Names
    N-acetyllacosaminide alpha 2,3-sialyltransferase
    N-acetyllactosaminide alpha-2,3-sialyltransferase
    beta-galactoside alpha-2,3-sialyltransferase 3
    gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase
    sialyltransferase (N-acetyllacosaminide alpha 23-sialyltransferase)
    sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
    sialyltransferase 6(N-acetyllacosaminide alpha 23-sialyltransferase)
    XP_006238777.1
    XP_006238778.1
    XP_038966633.1
    XP_038966634.1
    XP_063144417.1
    XP_063144418.1
    XP_063144419.1
    XP_063144420.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429992.1 → NP_001416921.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JZG3, F1LM32

    2. NM_001430000.1 → NP_001416929.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6GDQ1

    3. NM_031697.2 → NP_113885.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JZG3, F1LM32
      Related
      ENSRNOP00000053685.2, ENSRNOT00000056842.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      136755780..136958081 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238715.4 → XP_006238777.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1

      Conserved Domains (1) summary
      pfam00777
      Location:106 → 370
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_063288350.1 → XP_063144420.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X4

      Related
      ENSRNOP00000086704.1, ENSRNOT00000097514.2

    3. XM_006238716.4 → XP_006238778.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X2

      Related
      ENSRNOP00000086133.1, ENSRNOT00000106433.2
      Conserved Domains (1) summary
      pfam00777
      Location:90 → 354
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_039110706.2 → XP_038966634.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:14 → 278
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_039110705.2 → XP_038966633.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:14 → 278
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_063288347.1 → XP_063144417.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    7. XM_063288349.1 → XP_063144419.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    8. XM_063288348.1 → XP_063144418.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02734.1 GenPept UniProtKB/Swiss-Prot:Q02734

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