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    Eif3f eukaryotic translation initiation factor 3, subunit F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293427, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Eif3fprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Fprovided by RGD
    Primary source
    RGD:1306112
    See related
    EnsemblRapid:ENSRNOG00000015221 AllianceGenome:RGD:1306112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif3s5
    Summary
    Predicted to enable identical protein binding activity; thiol-dependent deubiquitinase; and translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 547.4), Spleen (RPKM 533.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif3f in Genome Data Viewer
    Location:
    1q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172369062..172378043)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (162934220..162943204)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (173532826..173541806)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 3C Neighboring gene NLR family, pyrin domain containing 10 Neighboring gene TUB bipartite transcription factor Neighboring gene high mobility group protein B1 pseudogene Neighboring gene RIC3 acetylcholine receptor chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of variations of gene expression of visceral adipose and renal tissue in type 2 diabetic rats using cDNA representational difference analysis. Yang J, et al. Chin Med J (Engl), 2003 Apr. PMID 12875716
    2. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. Moretti J, et al. PLoS Biol, 2010 Nov 23. PMID 21124883, Free PMC Article
    3. Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. Sizova DV, et al. J Virol, 1998 Jun. PMID 9573242, Free PMC Article
    4. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article
    5. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex, eIF3m ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit F
    Names
    eukaryotic translation initiation factor 3, subunit 5 (epsilon)
    NP_001264231.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277302.1 → NP_001264231.1  eukaryotic translation initiation factor 3 subunit F

      Status: VALIDATED

      Source sequence(s)
      FQ213714, FQ230130
      UniProtKB/TrEMBL
      D4AC36
      Related
      ENSRNOP00000021017.6, ENSRNOT00000021017.9
      Conserved Domains (1) summary
      cd08064
      Location:96 → 358
      MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      172369062..172378043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106292.1: Suppressed sequence

      Description
      NM_001106292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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