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    ZNF727 zinc finger protein 727 [ Homo sapiens (human) ]

    Gene ID: 442319, updated on 17-Jun-2024

    Summary

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    Official Symbol
    ZNF727provided by HGNC
    Official Full Name
    zinc finger protein 727provided by HGNC
    Primary source
    HGNC:HGNC:22785
    See related
    Ensembl:ENSG00000214652 AllianceGenome:HGNC:22785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF727P
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thyroid (RPKM 2.3), ovary (RPKM 1.5) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF727 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64045434..64085339)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65253324..65293248)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63505812..63545717)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1005 Neighboring gene uncharacterized LOC105375317 Neighboring gene tripartite motif containing 60 pseudogene 17 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:63560238-63560738 Neighboring gene GUSB pseudogene 6 Neighboring gene MT-ND4L pseudogene 2 Neighboring gene MT-ND4 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. Wang W, et al. PLoS One, 2014. PMID 24647005, Free PMC Article
    2. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
    3. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940
    4. A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells. Kleiner RE, et al. Cell Chem Biol, 2018 Jan 18. PMID 29104064, Free PMC Article
    5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative zinc finger protein 727
    Names
    zinc finger protein 727 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159522.3 → NP_001152994.1  putative zinc finger protein 727

      See identical proteins and their annotated locations for NP_001152994.1

      Status: VALIDATED

      Source sequence(s)
      AC115220, DA235663
      Consensus CDS
      CCDS55113.1
      UniProtKB/Swiss-Prot
      A8MUV8
      Related
      ENSP00000485448.1, ENST00000456806.3
      Conserved Domains (6) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:296 → 465
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:392 → 477
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:148 → 167
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      64045434..64085339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012225.3 → XP_016867714.1  putative zinc finger protein 727 isoform X1

    RNA

    1. XR_242241.4 RNA Sequence

    2. XR_927469.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      65253324..65293248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358264.1 → XP_054214239.1  putative zinc finger protein 727 isoform X1

    RNA

    1. XR_008487617.1 RNA Sequence

    2. XR_008487618.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_011772.1: Suppressed sequence

      Description
      NG_011772.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MUV8.3 GenPept UniProtKB/Swiss-Prot:A8MUV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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