NBAT1 neuroblastoma associated transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NBAT1provided by HGNC
Official Full Name: neuroblastoma associated transcript 1provided by HGNC
Primary source: HGNC:HGNC:49075
See related: MIM:616206; AllianceGenome:HGNC:49075
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CASC14; NBAT-1
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6p22.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (22134602..22147193, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (22007424..22020017, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (22134831..22147422, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression level and clinical significance of NBAT-1 in human cancers: a systematic review and meta-analysis.
Title: Expression level and clinical significance of NBAT-1 in human cancers: a systematic review and meta-analysis.
Serum lncRNAs, NBAT-1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C.
Title: Serum lncRNAs, NBAT-1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C.
Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression.
Title: Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression.
Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma.
Title: Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma.
Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer.
Title: Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer.
Low NBAT1 expression is associated with cell proliferation, migration, and invasion in renal carcinoma.
Title: LncRNA NBAT1 suppresses cell proliferation and migration via miR-346/GSK-3β axis in renal carcinoma.
NBAT-1 overexpression remarkably upregulated PTEN expression in gastric cancer (GC) cells. Low expression of NBAT-1 promotes GC development by downregulating PTEN expression.
Title: Low expression of lncRNA NBAT-1 promotes gastric cancer development and is associated with poor prognosis.
Up-regulation of NBAT1 inhibited proliferative activities of glioblastoma tumor cells by regulating Akt activity.
Title: Effect of downregulated lncRNA NBAT1 on the biological behavior of glioblastoma cells.
The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1.
Title: LncRNA NBAT-1 is down-regulated in lung cancer and influences cell proliferation, apoptosis and cell cycle.
DKK1 is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1's effects in inhibiting migration and invasion of breast cancer cells.
Title: NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Integrative genomics identifies LMO1 as a neuroblastoma oncogene. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

SGC36817 (e-PCR)
- UniSTS:8973

A004M23 (e-PCR)
- UniSTS:75627

RH64859 (e-PCR)
- UniSTS:18056

G67603 (e-PCR)
- UniSTS:224152

RH46644 (e-PCR)
- UniSTS:409

Other Names

cancer susceptibility candidate 14 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.