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    Gtf3c3 general transcription factor IIIC subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316810, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Gtf3c3provided by RGD
    Official Full Name
    general transcription factor IIIC subunit 3provided by RGD
    Primary source
    RGD:1309185
    See related
    EnsemblRapid:ENSRNOG00000002091 AllianceGenome:RGD:1309185
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 173.2), Adrenal (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf3c3 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (63375860..63437475, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (55882252..55943037, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (60999159..61033612, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 150 Neighboring gene ribosomal protein L31 like 12 Neighboring gene uncharacterized LOC134480576 Neighboring gene similar to human chromosome 2 open reading frame 66 Neighboring gene post-GPI attachment to proteins inositol deacylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385
    2. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase III general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 3
    Names
    general transcription factor IIIC, polypeptide 3, 102kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108239.1 → NP_001101709.1  general transcription factor 3C polypeptide 3

      See identical proteins and their annotated locations for NP_001101709.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473965
      UniProtKB/TrEMBL
      A0A8I5ZPB3, A6INZ7, D4A7Q9
      Related
      ENSRNOP00000002864.5, ENSRNOT00000002864.7
      Conserved Domains (3) summary
      sd00006
      Location:180 → 208
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:213 → 277
      TPR_11; TPR repeat
      pfam13432
      Location:422 → 486
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      63375860..63437475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267350.1 → XP_063123420.1  general transcription factor 3C polypeptide 3 isoform X1

      Related
      ENSRNOP00000101787.1, ENSRNOT00000174029.1

    2. XM_039083807.2 → XP_038939735.1  general transcription factor 3C polypeptide 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K945, A0A8I5ZPB3
      Conserved Domains (2) summary
      TIGR02917
      Location:142 → 511
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:180 → 208
      TPR; TPR repeat [structural motif]

    3. XM_008767115.4 → XP_008765337.1  general transcription factor 3C polypeptide 3 isoform X3

      Conserved Domains (3) summary
      sd00006
      Location:180 → 208
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:215 → 247
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:213 → 277
      TPR_11; TPR repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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