FNDC8 fibronectin type III domain containing 8 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FNDC8provided by HGNC
Official Full Name: fibronectin type III domain containing 8provided by HGNC
Primary source: HGNC:HGNC:25286
See related: Ensembl:ENSG00000073598 AllianceGenome:HGNC:25286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis (RPKM 39.7) and brain (RPKM 1.6) See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (35121615..35130732)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (36069529..36078645)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (33448634..33457751)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: fibronectin type III domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_054719.1 RefSeqGene

Range

5037..14154

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_017559.4 → NP_060029.1 fibronectin type III domain-containing protein 8

Status: VALIDATED

Source sequence(s)

AK313775, AL133054, BC024002

Consensus CDS

CCDS11290.1

UniProtKB/Swiss-Prot

B2R9G6, Q8TC99, Q9UFC2

Related

ENSP00000158009.4, ENST00000158009.6

Conserved Domains (1) summary

cd00063
Location:179 → 277

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...