Snx19 sorting nexin 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snx19provided by RGD
Official Full Name: sorting nexin 19provided by RGD
Primary source: RGD:1309857
See related: EnsemblRapid:ENSRNOG00000014719 AllianceGenome:RGD:1309857
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to act upstream of or within chondrocyte differentiation; dense core granule maturation; and insulin secretion. Predicted to be located in cytoplasm. Predicted to be active in early endosome membrane. Orthologous to human SNX19 (sorting nexin 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 168.4), Kidney (RPKM 159.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (37088142..37125317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (28829881..28867600)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (31497034..31534077)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW529649 (e-PCR)
- UniSTS:247420

BE096949 (e-PCR)
- UniSTS:260740

RH144420 (e-PCR)
- UniSTS:233665

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dense core granule maturation	ISO Inferred from Sequence Orthology more info
involved_in dense core granule maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sorting nexin-19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108131.2 → NP_001101601.2 sorting nexin-19 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

Related

ENSRNOP00000020041.7, ENSRNOT00000020041.8
NM_001429801.1 → NP_001416730.1 sorting nexin-19 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001429802.1 → NP_001416731.1 sorting nexin-19 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RNA

NR_190791.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

37088142..37125317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242747.5 → XP_006242809.1 sorting nexin-19 isoform X1

Conserved Domains (3) summary

cd06893
Location:440 → 567

PX_SNX19; The phosphoinositide binding Phox Homology domain of Sorting Nexin 19

pfam08628
Location:753 → 853

Nexin_C; Sorting nexin C terminal

cl02564
Location:95 → 265

PXA; PXA domain
XM_063265353.1 → XP_063121423.1 sorting nexin-19 isoform X2