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    Fbxo7 F-box protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366854, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Fbxo7provided by RGD
    Official Full Name
    F-box protein 7provided by RGD
    Primary source
    RGD:1305648
    See related
    EnsemblRapid:ENSRNOG00000004637 AllianceGenome:RGD:1305648
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme binding activity; protein heterodimerization activity; and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of neuron death and positive regulation of autophagy of mitochondrion. Predicted to be located in several cellular components, including Lewy body core; Lewy body corona; and Lewy neurite. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 193.3), Adrenal (RPKM 173.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo7 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (19696951..19725180, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (17809224..17837549, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (23815246..23843505, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene synapsin III Neighboring gene uncharacterized LOC134479850 Neighboring gene uncharacterized LOC134479849 Neighboring gene U6 spliceosomal RNA Neighboring gene BPI fold containing family C Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15). Zhao T, et al. PLoS One, 2011 Feb 11. PMID 21347293, Free PMC Article
    2. FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease. Chen CM, et al. PLoS One, 2014. PMID 25029497, Free PMC Article
    3. FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy. Zhao T, et al. J Neuropathol Exp Neurol, 2013 Jun. PMID 23656991
    4. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. Meziane el K, et al. J Cell Sci, 2011 Jul 1. PMID 21652635
    5. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Chang YF, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16510124

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy of mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Lewy body core ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Lewy body corona ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Lewy neurite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in classical Lewy body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in glial cytoplasmic inclusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012222.1 → NP_001012222.1  F-box only protein 7

      See identical proteins and their annotated locations for NP_001012222.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079382
      UniProtKB/Swiss-Prot
      Q68FS3
      UniProtKB/TrEMBL
      A6IFC7
      Related
      ENSRNOP00000006366.5, ENSRNOT00000006366.9
      Conserved Domains (5) summary
      PHA03247
      Location:422 → 515
      PHA03247; large tegument protein UL36; Provisional
      pfam06881
      Location:371 → 408
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:193 → 317
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:335 → 376
      F-box-like
      cl28922
      Location:1 → 77
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      19696951..19725180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079673.2 → XP_038935601.1  F-box only protein 7 isoform X2

      UniProtKB/TrEMBL
      A6IFC8
      Conserved Domains (4) summary
      PHA03247
      Location:284 → 377
      PHA03247; large tegument protein UL36; Provisional
      pfam06881
      Location:233 → 270
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:55 → 179
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:197 → 238
      F-box-like

    2. XM_006241166.4 → XP_006241228.1  F-box only protein 7 isoform X1

      Conserved Domains (3) summary
      pfam06881
      Location:292 → 329
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:110 → 242
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:256 → 299
      F-box-like; F-box-like

    3. XM_006241167.3 → XP_006241229.1  F-box only protein 7 isoform X3

      See identical proteins and their annotated locations for XP_006241229.1

      Conserved Domains (4) summary
      PHA03247
      Location:341 → 434
      PHA03247; large tegument protein UL36; Provisional
      pfam06881
      Location:290 → 327
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:112 → 236
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:254 → 295
      F-box-like

    4. XM_039079674.2 → XP_038935602.1  F-box only protein 7 isoform X2

      UniProtKB/TrEMBL
      A6IFC8
      Conserved Domains (4) summary
      PHA03247
      Location:284 → 377
      PHA03247; large tegument protein UL36; Provisional
      pfam06881
      Location:233 → 270
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:55 → 179
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:197 → 238
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FS3.1 GenPept UniProtKB/Swiss-Prot:Q68FS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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