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    Dhrs7c dehydrogenase/reductase 7C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287411, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dhrs7cprovided by RGD
    Official Full Name
    dehydrogenase/reductase 7Cprovided by RGD
    Primary source
    RGD:1306989
    See related
    Ensembl:ENSRNOG00000026548 AllianceGenome:RGD:1306989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306989
    Summary
    Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in longitudinal sarcoplasmic reticulum. Predicted to be active in sarcoplasmic reticulum membrane. Orthologous to human DHRS7C (dehydrogenase/reductase 7C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 1220.2) and Heart (RPKM 581.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrs7c in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52994205..53012281)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (52495262..52513338)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (54352270..54370653)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glucagon-like peptide 2 receptor Neighboring gene GSG1-like 2 Neighboring gene ubiquitin specific peptidase 43 Neighboring gene uncharacterized LOC100911946

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase. Treves S, et al. Biochem J, 2012 Jan 15. PMID 21995425
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in longitudinal sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in longitudinal sarcoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 7C
    Names
    dehydrogenase/reductase (SDR family) member 7C
    sarcoplasmic reticulum protein of 35 kDa
    short-chain dehydrogenase/reductase family 32C member 2
    NP_001258526.1
    NP_001258527.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271597.1 → NP_001258526.1  dehydrogenase/reductase SDR family member 7C isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFJ2
      Conserved Domains (1) summary
      cl21454
      Location:35 → 214
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001271598.1 → NP_001258527.1  dehydrogenase/reductase SDR family member 7C isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      FM120380, FN805189, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZGP9
      Related
      ENSRNOP00000031559.4, ENSRNOT00000036752.7
      Conserved Domains (2) summary
      cd05332
      Location:35 → 296
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      PRK06181
      Location:37 → 293
      PRK06181; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52994205..53012281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZGP9.1 GenPept UniProtKB/Swiss-Prot:D3ZGP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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