U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58981, updated on 28-Oct-2024

    Summary

    Official Symbol
    Kcnab3provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily A regulatory beta subunit 3provided by RGD
    Primary source
    RGD:61830
    See related
    EnsemblRapid:ENSRNOG00000008480 AllianceGenome:RGD:61830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 48.3), Thymus (RPKM 17.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnab3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54546638..54555209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54047830..54056401)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55927228..55933653)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 2D, retinal Neighboring gene U6 spliceosomal RNA Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene ring finger protein 227 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene chromodomain helicase DNA binding protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    voltage-gated potassium channel subunit beta-3
    Names
    K(+) channel subunit beta-3
    RCK beta3
    kv-beta-3
    potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3
    potassium channel, voltage gated subfamily A regulatory beta subunit 3
    potassium voltage gated channel, shaker related subfamily, beta member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031652.2NP_113840.1  voltage-gated potassium channel subunit beta-3

      See identical proteins and their annotated locations for NP_113840.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q2KML7, Q63494
      Related
      ENSRNOP00000011523.3, ENSRNOT00000011523.7
      Conserved Domains (2) summary
      cd06660
      Location:80395
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
      TIGR01293
      Location:80396
      Kv_beta; voltage-dependent potassium channel beta subunit, animal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54546638..54555209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086719.2XP_038942647.1  voltage-gated potassium channel subunit beta-3 isoform X1

      Related
      ENSRNOP00000103130.1, ENSRNOT00000122661.1
      Conserved Domains (1) summary
      cl00470
      Location:68386
      AKR_SF; Aldo-keto reductase (AKR) superfamily