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    AHP1 thioredoxin peroxidase AHP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850799, updated on 9-Jun-2024

    Summary

    Gene symbol
    AHP1
    Gene description
    thioredoxin peroxidase AHP1
    Primary source
    FungiDB:YLR109W
    Locus tag
    YLR109W
    See related
    SGD:S000004099; AllianceGenome:SGD:S000004099; VEuPathDB:YLR109W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thioredoxin peroxidase activity. Involved in cell redox homeostasis; cellular response to oxidative stress; and response to metal ion. Located in cytoplasm. Orthologous to human PRDX5 (peroxiredoxin 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See AHP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (368781..369311)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ccw12p Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thioredoxin peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thioredoxin peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thioredoxin peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thioredoxin-dependent peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane HDA PubMed 

    General protein information

    Preferred Names
    thioredoxin peroxidase AHP1
    NP_013210.1
    • Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      368781..369311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181996.1NP_013210.1  TPA: thioredoxin peroxidase AHP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013210.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYA9, P38013
      UniProtKB/TrEMBL
      A0A6A5PW61, A7A113, B3LT76, B5VN47, C7GQT1, C8ZD80, G2WIV3, N1NZ91
      Conserved Domains (1) summary
      COG0678
      Location:1176
      AHP1; Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]