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    MAK11 Mak11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853847, updated on 1-Aug-2024

    Summary

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    Gene symbol
    MAK11
    Gene description
    Mak11p
    Primary source
    FungiDB:YKL021C
    Locus tag
    YKL021C
    See related
    SGD:S000001504; AllianceGenome:SGD:S000001504; VEuPathDB:YKL021C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and ribosomal large subunit assembly. Located in membrane. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MAK11 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (397344..398750, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Ska1p Neighboring gene anaphase promoting complex subunit CDC16 Neighboring gene Spt23p Neighboring gene bifunctional protein farnesyltransferase/protein geranylgeranyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein. Icho T, et al. J Biol Chem, 1988 Jan 25. PMID 2826479
    2. Mak mutants of yeast: mapping and characterization. Wickner RB, et al. J Bacteriol, 1979 Oct. PMID 387719, Free PMC Article
    3. Molecular characterization of chromosomal genes affecting double-stranded RNA replication in Saccharomyces cerevisiae. Icho T, et al. Basic Life Sci, 1986. PMID 3551912
    4. Yeast virus propagation depends critically on free 60S ribosomal subunit concentration. Ohtake Y, et al. Mol Cell Biol, 1995 May. PMID 7739558, Free PMC Article
    5. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mak11p
    NP_012904.3
    • Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      397344..398750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179587.3 → NP_012904.3  TPA: Mak11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012904.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A6ZZU3, B3LR63, B5VMD2, G2WI09, N1NZA9
      Conserved Domains (2) summary
      sd00039
      Location:109 → 144
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:98 → 384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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