RDI1 Rdi1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RDI1
Official Full Name: Rdi1p
Primary source: SGD:S000002294
Locus tag: YDL135C
See related: AllianceGenome:SGD:S000002294; FungiDB:YDL135C; VEuPathDB:YDL135C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables Rho GDP-dissociation inhibitor activity. Involved in Rho protein signal transduction; actin filament organization; and regulation of vacuole fusion, non-autophagic. Located in cellular bud neck; cellular bud tip; and cytosol. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to several human genes including ARHGDIA (Rho GDP dissociation inhibitor alpha) and ARHGDIB (Rho GDP dissociation inhibitor beta). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Rdi1p inhibited membrane fusion.
Title: Functional analysis of RhoGDI inhibitory activity on vacuole membrane fusion.
Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms
Title: The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms.
Rdi1p functions in cell cycle-specific Cdc42p membrane detachment.
Title: Analysis of cell-cycle specific localization of the Rdi1p RhoGDI and the structural determinants required for Cdc42p membrane localization and clustering at sites of polarized growth.
Data from these studies have facilitated the temporal and spatial modeling of Rdi1p-dependent extraction of Cdc42p from the plasma membrane during the cell cycle.
Title: Use of bimolecular fluorescence complementation to study in vivo interactions between Cdc42p and Rdi1p of Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho GDP-dissociation inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables Rho GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rho protein signal transduction	IPI Inferred from Physical Interaction more info	PubMed
involved_in actin filament organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vacuole fusion, non-autophagic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed

NP_010146.1

Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress