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    F49H6.5 GTP 3',8-cyclase [ Caenorhabditis elegans ]

    Gene ID: 186073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    F49H6.5
    Official Full Name
    GTP 3',8-cyclase
    Primary source
    WormBase:WBGene00009908
    Locus tag
    CELE_F49H6.5
    See related
    AllianceGenome:WB:WBGene00009908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See F49H6.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (17023241..17025527)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MS Related Protein Neighboring gene MS Related Protein Neighboring gene Secreted protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP 3',8'-cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP 3',8'-cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTP 3',8-cyclase
    NP_001368565.1
    • Confirmed by transcript evidence
    NP_001370025.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      17023241..17025527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383480.1 → NP_001370025.1  GTP 3',8-cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XV04
      Conserved Domains (1) summary
      PLN02951
      Location:67 → 389
      PLN02951; Molybderin biosynthesis protein CNX2

    2. NM_001380850.1 → NP_001368565.1  GTP 3',8-cyclase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVJ9
      Conserved Domains (1) summary
      PLN02951
      Location:2 → 322
      PLN02951; Molybderin biosynthesis protein CNX2
    Nucleotide Protein
    Heading Accession and Version

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