K11H3.3 Putative tricarboxylate transport protein, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K11H3.3
Official Full Name: Putative tricarboxylate transport protein, mitochondrial
Primary source: WormBase:WBGene00010780
Locus tag: CELE_K11H3.3
See related: AllianceGenome:WB:WBGene00010780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable citrate secondary active transmembrane transporter activity. Predicted to be involved in mitochondrial citrate transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in 2-hydroxyglutaric aciduria; combined D-2- and L-2-hydroxyglutaric aciduria; and congenital myasthenic syndrome. Orthologous to human SLC25A1 (solute carrier family 25 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See K11H3.3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (9851854..9853826)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11H3.3 (e-PCR)
- UniSTS:311923

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables citrate secondary active transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial citrate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Putative tricarboxylate transport protein, mitochondrial

NP_499187.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9851854..9853826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066786.6 → NP_499187.1 Putative tricarboxylate transport protein, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499187.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34519

Conserved Domains (1) summary

pfam00153
Location:225 → 304

Mito_carr; Mitochondrial carrier protein