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    Y50D7A.10 ADF-H domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259487, updated on 12-Jun-2024

    Summary

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    Gene symbol
    Y50D7A.10
    Gene description
    ADF-H domain-containing protein
    Locus tag
    CELE_Y50D7A.10
    See related
    AllianceGenome:WB:WBGene00021758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable Arp2/3 complex binding activity. Predicted to be involved in actin filament debranching and negative regulation of Arp2/3 complex-mediated actin nucleation. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Y50D7A.10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (315460..321716)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 30S ribosomal protein S15;Peptidase metallopeptidase domain-containing protein Neighboring gene DUF295 domain-containing protein;F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Alkyldihydroxyacetonephosphate synthase Neighboring gene PDZ domain-containing protein Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cellular component biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADF-H domain-containing protein
    NP_871652.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      315460..321716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181923.6 → NP_871652.2  ADF-H domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871652.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IAA5
      Conserved Domains (1) summary
      cd11283
      Location:9 → 130
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    Nucleotide Protein
    Heading Accession and Version

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