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    W02F12.2 Alkaline ceramidase [ Caenorhabditis elegans ]

    Gene ID: 189124, updated on 2-Nov-2024

    Summary

    Official Symbol
    W02F12.2
    Official Full Name
    Alkaline ceramidase
    Primary source
    WormBase:WBGene00020947
    Locus tag
    CELE_W02F12.2
    See related
    AllianceGenome:WB:WBGene00020947
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in ceramide catabolic process and sphingosine biosynthetic process. Predicted to be located in Golgi membrane. Orthologous to several human genes including ACER1 (alkaline ceramidase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See W02F12.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (6695177..6697652, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Metallothionein-1 Neighboring gene Metallothionein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Embryonic mRna (mRNA) Anterior Neighboring gene Exonuclease domain-containing protein

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables N-acylsphingosine amidohydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingosine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Alkaline ceramidase
    NP_001370798.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6695177..6697652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383326.2NP_001370798.1  Alkaline ceramidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45145
      Conserved Domains (1) summary
      pfam05875
      Location:18265
      Ceramidase