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    R02D3.8 Exonuclease domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176845, updated on 2-Nov-2024

    Summary

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    Official Symbol
    R02D3.8
    Official Full Name
    Exonuclease domain-containing protein
    Primary source
    WormBase:WBGene00019825
    Locus tag
    CELE_R02D3.8
    See related
    AllianceGenome:WB:WBGene00019825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity. Involved in PERK-mediated unfolded protein response and innate immune response. Predicted to be active in cytoplasm. Orthologous to human ERI3 (ERI1 exoribonuclease family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See R02D3.8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (255966..257203, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Saccharopine dehydrogenase Neighboring gene Ground-like domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene WW domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response HEP PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Exonuclease domain-containing protein
    NP_499887.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      255966..257203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067486.4 → NP_499887.1  Exonuclease domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZZ9
      Conserved Domains (1) summary
      cd06133
      Location:61 → 240
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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